Ipamorelin is a more recently developed synthetic GHRP (growth hormone releasing peptide) that exhibits strong (GH) growth hormone releasing properties. In specific rats, Ipamorelin released GH with a potency and efficacy comparable to GHRP-6. The same study reported that Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH (adrenocorticotropic hormone) and cortisol. It was noted that ipamorelin did not release ACTH or cortisol in levels significantly different from those seen following GHRH administration, even at very high doses. This study concluded by saying that ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to GHRH, making it a very interesting candidate for future clinical development.
Ipamorelin and GHRP 2
Ipamorelin is a 3rd generation GHRP behind GHRP-6 and GHRP-2. Ipamorelin has very similar characteristics of GHRP-2: does not have ghrelin’s lipogenic properties and does not promote hunger. Ipamorelin acts synergistically when applied during a Growth Hormone Releasing Hormone (GHRH) pulse or when it is administered along with a GHRH or an analog such as Sermorelin or Modified GRF 1-29 (growth releasing factor, aminos 1-29). The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH. On the other hand, Ipamorelin is similar to GHRP-6 because they both release GH at a very similar strength minus the side effects that of GHRP-6. Both GHRP-6 and GHRP-2 cause a release and an increase in cortisol and prolactin levels, however Ipamorelin only selectively releases GH at any dose. Ipamorelin shares similar functionality to Hexarelin and compared to other peptides, it is a much more stable form of ghrelin and has longer half-life periods of at least two hours long and causes secondary effect by making neurons to become excited.
Ipamorelin Benefits in a research environment
Ipamorelin has been shown to be both highly potent and very selective in vivo and vitro situations, and has also demonstrated good safety and tolerability in human clinical studies. Research has shown that Ipamorelin is growth hormone specific which means that the pituitary hormones such as cortisol are unaffected. In one study, it was found that young female adult rats had increased bone mass due to 12 weeks of treatment with ipamorelin. This peptide compared to other Growth Hormone Releasing Peptides ensures the benefits without having to deal with possible negative side effects.
|Unit Size||2 mg/vial|
|Unit Quantity||1 Vial|
|Solubility||>Soluble in water or 1% acetic acid|
|Storage||Lyophilized Ipamorelin is stable at room temperature for 90 days, however it should be stored in a freezer below -8C for any extended period of time.|
|Safety Information||For Research Only. Not Intended for Diagnostic or Therapeutic Use.|
Although there has actually been a substantial quantity of study and also research study carried out in regard to Ipamorelin, it has to be kept in mind that of the research study that has actually been performed as well as the succeeding arise from such research study has actually been only constructed around the clinical research based upon animal test subjects. For that reason, any type of searching for or monitoring that associate with Ipamorelin ought to just be included to the stringent boundaries of a regulated atmosphere such as a clinical study center or a research laboratory. This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.