Modified GRF (1-29), CJC-1295 no DAC
Modified Growth Releasing Factor aminos 1-29, usually referred to as Modified GRF (1-29) or “ModGRF(1-29),” also known as CJC-1295 without DAC, is a synthetic analog of the endogenous peptide signaling hormone Growth Hormone Releasing Hormone (GHRH). Endogenously produced GHRH has 44 amino acids in its chain structure. A truncated synthetic form of GHRH called Sermorelin or GRF 1-29 has 29 amino acids; Modified GRF (1-29) is further changed in that it has four substituted aminos in its chain that serve the purposes of preventing degradation and oxidation in manufacture and transport as well as in vivo, while also increasing binding affinity to the GHRH receptors.
Modified GRF (1-29) is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation.
CJC-1295 DAC vs. CJC-1295 No DAC.
CJC-1295 DAC and also CJC-1295 (additionally referred to as modified GRF 1-29) are both growth hormonal releasing hormone (GHRH). Their activity in the body equals however the distinction in between both peptides are the period of the half-life. Customized GRF 1-29 and also Sermorelin have a really brief acting half-life of about thirty minutes, while CJC-1295 DAC has a half-life that could last as much as roughly 8 days. Extensive research has shown that the brief half-life of Sermorelin as well as Modified GRF 1-29 has a more all-natural brief pulse of (GHRH).
|Unit Size||2 mg/vial|
|Unit Quantity||1 Vial|
|Solubility||>Soluble in water or 1% acetic acid|
|Storage||Lyophilized CJC-1295 W/O DAC is stable at room temperature for 90 days, however it should be stored in a freezer below -8C for any extended period of time.|
|Safety Information||For Research Only. Not Intended for Diagnostic or Therapeutic Use.|
Although there has actually been a substantial quantity of study and also research study carried out in regard to Modified GRF (1-29), CJC-1295 no DAC, it has to be kept in mind that of the research study that has actually been performed as well as the succeeding arise from such research study has actually been only constructed around the clinical research based upon animal test subjects. For that reason, any type of searching for or monitoring that associate with Modified GRF (1-29), CJC-1295 no DAC ought to just be included to the stringent boundaries of a regulated atmosphere such as a clinical study center or a research laboratory. This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.