Fragment 176-191 is a peptide fragment of the C-terminus of human Growth Hormone. Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the Growth Hormone molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. Like Growth Hormone, the hgH fragment 176-191 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food materials into body fat) both in laboratory testing and in animals.
Research Laboratory Examinations and also Weight Loss.
These segments of the synthetic peptide GH 176-191 have been investigated for their in vivo effects in laboratory mice musculus. Research results have shown that gH 176-191 have resulted to a short-period increase in blood glucose and a more sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191. In addition, the researchers have suggested that functionality of the peptide depends not only in the informational sequence but should also have the correct physical configuration (Ng and Borstein 1978). Also, this fragment, being a region of high accessibility to proteases and also rich in proline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains. This then suggest that such residue is significant in conformational changes be serving as sites for peripheral protein binding in some body cells (Low et al. 1984).
Fragment 176-191 as an Active HGH Truncated Peptide
In another study of Ng et al. (2000) on animal subjects, they found out that a 500mcg dosage of the said hormone increased the lipolytic activity in adipose tissues without having negative influence in the blood glucose level. Furthermore, though it behaves like a human growth hormone (hgH), it does not causes hyperglycemia because it does not compete with hgH receptors (Wu et al. 1993). Because of such effects, researchers have suggested that it might be used for the elimination of excess abdominal fat which is a significant aspect of HIV-associated lipodystrophy.
The (gH fragment 176-191) exhibits the ability to burn through stubborn adipose tissue, while increasing energy expenditure, muscle mass, and fat oxidation. All studies have pointed to the fact that the fragment is an effective treatment for obesity and fat loss, and much safer than its Human Growth Hormone counterpart.
|Unit Size||5 mg/vial|
|Unit Quantity||1 Vial|
|Solubility||>Soluble in water or 1% acetic acid|
|Storage||Lyophilized FRAG 176-191 is stable at room temperature for 90 days, however it should be stored in a freezer below -8C for any extended period of time.|
|Safety Information||For Research Only. Not Intended for Diagnostic or Therapeutic Use.|
Although there has actually been a substantial quantity of study and also research study carried out in regard to HGH Fragment 176-191, it has to be kept in mind that of the research study that has actually been performed as well as the succeeding arise from such research study has actually been only constructed around the clinical research based upon animal test subjects. For that reason, any type of searching for or monitoring that associate with Fragment 176-191 ought to just be included to the stringent boundaries of a regulated atmosphere such as a clinical study center or a research laboratory.