MGF vs PEG MGF Half Life
Base MGF which is produced in liver and secreted into the blood stream, only lasts for about 5-7 minutes before it breaks down. This is the regular “base” MGF version that’s not widely used due to the short half-life. Just as IGF-1 was modified to be IGF-1LR3 (the longer acting version), the same has been done with MGF. The additive polyethylene glycol was added to the MGF chain in order to give it a half life of several days.
Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue. MGF as IGF-IEa is a bit of a technical term and harder to identify amongst the other IGF variants.
What makes MGF special is its’ unique role in muscle growth. MGF has the ability to cause wasted tissue to grow and improve by activating muscle stem cells and increasing the upregulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth. MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-1 receptor domain which, in turn, increases protein synthesis turnover; therefore, if used correctly it can improve muscle mass over time.
The liver produces 2 kinds of MGF splice variants of IGF
1) IGF-1Ec: This is the first phase release igf splice variant and it appears to stimulate satellite cells into activation, This is the closest variant to synthetic MGF.
2) Liver type IGF-IEa: this is the secondary release of igf from the liver, and its far less anabolic.
MGF differs from the second variant IGF-IEa as it has a different peptide sequence which is responsible for replenishing the satellite cells in skeletal muscle; in other words, it is more anabolic and longer acting than the systematic release of the second MGF liver variant.
MGF as a highly anabolic variant of igf. IGF-I gene is spliced towards MGF then that causes hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as other important anabolic processes, including the above mentioned protein synthesis, and increased nitrogen retention.
What happens to your muscles is they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant. The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die.
As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair, if the cells are not repaired they die and your muscles get smaller and weaker. In muscle tissue, the pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.
|Unit Size||2 mg/vial|
|Unit Quantity||1 Vial|
|Solubility||>Soluble in water or 1% acetic acid|
|Storage||Lyophilized PEG-MFG is stable at room temperature for 90 days, however it should be stored in a freezer below -8C for any extended period of time.|
|Safety Information||For Research Only. Not Intended for Diagnostic or Therapeutic Use.|
Although there has actually been a substantial quantity of study and also research study carried out in regard to PEG MGF, it has to be kept in mind that of the research study that has actually been performed as well as the succeeding arise from such research study has actually been only constructed around the clinical research based upon animal test subjects. For that reason, any type of searching for or monitoring that associate with PEG MGF ought to just be included to the stringent boundaries of a regulated atmosphere such as a clinical study center or a research laboratory. This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.