What is Melanotan 2 Peptide

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Melanotan refers to a series of synthetic hormones that are created in laboratories. There are three main compounds that are associated with this class of synthetic hormones, including Melanotan I, Melanotan ii, and a newer variety that is derived from the melanotan ii compound, known as bremelanotide.

While Melanotan I was developed as a tanning compound that does not require exposure to sun rays, Melanotan ii was developed with a similar purpose, but later studies found that a side-effect caused men to experience spontaneous erections while injected with the synthetic hormone. Specific compounds were extracted from the Melanotan ii drug later on in order to develop bremelanotide, which was designed to assist in the treatment of erectile dysfunction specifically.

What Is Melanotan 2

Melanotan 2 is a type of laboratory-developed substance that acts in a similar way as a natural hormone that is found in the human body, known as an alpha-melanocyte stimulating hormone. The initial purpose of the hormone was to induce an effect that causes the skin to become darker – this was achieved without the need to be exposed to sunlight for a tanning effect.

After several studies were performed on the compound, scientists found the use of this synthetic hormone led to spontaneous erections in men treated with the synthetic hormone. This led to further research into the topic of using Melanotan 2 as a way to produce erections in men who have been diagnosed with a condition like erectile dysfunction. Since this discovery, numerous Melanotan research studies have been conducted to produce more accurate evidence – not only on the potential usefulness of the compound but also to assist in understanding the safety of the synthetic hormone.

Melanotan 2 Benefits

Melanotan 2 has been suggested for the use in three different scenarios, but insufficient research is currently available to support all of the suggested uses for this particular compound. In particular, the following benefits may be acquired through an injection that contains Melanotan 2 synthetic hormones:

  • The primary purpose of Melanotan’s initial development was due to the tanning effect that it induced when injected underneath the skin. Following the use of this synthetic hormone, appropriate receptors in the body would be activated, which leads to a darkening of the skin.
  • Melanotan 2 has also been suggested as a potential option for men struggling with their erectile function. Studies have suggested that the compound may help to induce spontaneous erections in men with diagnosed erectile dysfunction and those with other sexual dysfunctions – the synthetic hormone may also be effective in providing a way to treat low libido in men and women.
  • While insufficient evidence is available, the use of Melanotan 2 has also bee recommended for the prevention of cancers that affect the skin as a result of excessive exposure to the sun. Further research is still required in order to confirm if the compound can be an effective prevention method for these conditions.

Melanotan 2 Side Effects

Several side-effects have been noted in studies that focused on determining the efficiency and safety profile of the Melanotan 2 compound in the treatment of erectile dysfunction, as well as when used as a sunless tanning agent.

Particular side-effects that have been noted among patients who have been treated with this particular compound include:

  • Nausea
  • A reduction in the patient’s appetite
  • Flushing
  • Fatigue and tiredness
  • Abdominal cramps

The fact that the compound may cause a darkening of the patient’s skin, as well as the fact that patients may experience spontaneous erections when they use the synthetic hormone, is sometimes considered a side-effect of the drug. After noting these side-effects, scientists have started to consider the side-effects potential benefits and started to use the drug for these particular purposes.

Melanotan Research

There are multiple research studies that have been conducted, including several Melanotan clinical trials, in order to determine how effective the compound may be in providing a way to tan the skin without the sun, as well as to assist in providing a way for men to treat erectile dysfunction without necessarily relying on medications like Viagra.

In one study1, male patients were administered an injection containing Melanotan 2. The purpose of the study was to determine both the effectiveness and safety profile of the synthetic hormone. The participants experienced improvements in penile erections. The effects of the substance remained active for up to five hours in the participants. Side-effects noted were mild and mostly included yawning and nausea.

While the study mentioned provided positive evidence related to the use of Melanotan 2, we should take note of another review paper2. A patient, aged 39, injected a high dose of the synthetic hormone. The purpose was to use the substance as a tanning agent. Following the injection, the patient was taken to the emergency room and was later admitted to the ICU for further treatment. The patient experienced a high temperature, along with an elevation in his blood pressure levels. His heart rate also increased.

Melanotan 2 dosage in a controlled research environment

Various doses of Melanotan 2 have been researched in order to find the most appropriate dosage of the substance for specific purposes. Generally, the following doses are advised3:

  • When used as a skin tanning agent, it is advised that approximately 0.025mg of Melanotan 2 is administered per kilogram of the patient’s body weight.
  • In men with erectile dysfunction, a similar dose of 0.25mg Melanotan 2 per kilogram of body weight is advised.

It is crucial that these recommended doses are followed, as excessive administration of the substance have been shown to cause potentially harmful complications in patients.


Melanotan 2 is a subtype of a range of synthetic hormones that act similar to a natural hormone that is found in the human body. The primary purpose of the hormone is to interact in several receptors in the human body, which leads to a darkening of the skin without UV exposure. Additional uses also exist for the compound, including to assist in producing erections in male patients with existing erectile dysfunction symptoms. While studies have provided evidence of the efficiency that the drug poses for these purposes, side-effects are of concern for medical scientists.


1 R.T. Dorr, R. Lines, N. Levine, C. Brooks, L. Xiang, V.J. Hruby, M.E. Hadley. Evaluation of Melanotan-II, s superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sciences. 1996. https://www.ncbi.nlm.nih.gov/pubmed/8637402

2 M.E. Nelson, S.M. Bryant, S.E. Aks. Melanotan II injection resulting in systemic toxicity and rhabdomyolysis. Journal of Clinical Toxicology. 5 Nov 2012. https://www.ncbi.nlm.nih.gov/pubmed/23121206

3 Melatonan-II. WebMD. https://www.webmd.com/vitamins/ai/ingredientmono-884/melanotan-ii

For educational/research purposes only. This is not medical advice.

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