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Research findings for PEG-MGF

International Peptide


PEG-MGF is the Pegylated form of MGF (Mechano Growth Factor). MGF is a splice variant of IGF-1, which has been shown in vitro as well as in vivo to induce growth and hypertrophy in mechanically stimulated or damaged muscle. Insulin-like growth factor genes appear to have evolved from a single insulin-like gene. This gene can be detected in invertebrates and seems to cause anti-apoptotic effects by maintaining terminally differentiated cells. MGF contains the core protein encoded by the exons 3 and 4, as well as a specific insert encoded by a region of exon 5.

What is PEG-MGF?

PEG MGF is a splice variant of the IGF produced by a frame shift if the IGF gene and PEGylated to improve stability.  PEG-MGF, or PEGylated Mechano Growth Factor, is a new and innovative form of the IGF produced by a frame shift if the IGF gene, namely Mechano Growth Factor (MGF), which is PEGylated to improve stability that outperforms natural MGF many times over.  MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes. Research has shown that PEG-MGF helps increase the muscle stem cell count, so that more may fuse and become part of adult male mice muscle cells.

Mechano Growth Factor (MGF) exhibits local effects in skeletal muscle and without cannot travel through the body without modification. The problem with synthetic Mechano Growth Factor (MGF) is that it is introduced intramuscularly and is water based so it goes into the blood stream. When used this way, Mechano Growth Factor (MGF) only remains stable in the blood stream for a few minutes. Biologically produced MGF is made locally and does not enter the bloodstream. It is also short acting so stability is not an issue. By PEGylating the Mechano Growth Factor (MGF) it is almost as efficient as local produced Mechano Growth Factor (MGF. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule. The polyethylene glycol groups protect the peptide but do not surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein.

Information is for educational/research purposes only. This is not medical advice.

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