PT-141 (Bremelanotide) is a synthetic peptide analogue of α-MSH that may elicit aphrodisiac effects through stimulation of melanocortin receptors. PT-141 (Bremelanotide) consists of seven amino acids and is a cyclic, shortened lactam variant of alpha-Melanocyte-stimulating hormone (α-MSH), a multifunctional peptide that regulates a broad array of physiological functions. In studies, bremelanotide was shown to induce lordosis in an animal model and was also effective in treating sexual dysfunction.
Research findings for PT 141
Bremelanotide, similarly to its analogues α-MSH and Melanotan II, acts as a non-selective agonist of all of the melanocortin receptors except MC2, where it lacks significant affinity. The reported activity of the compound is as follows:
MC1 (Ki = 0.68 nM)
MC2 (Ki > 1000 nM)
MC3 (Ki = 72.07 nM)
MC4 (Ki = 19.25 nM)
MC5 (Ki = 166.8 nM)
Bremelanotide appears to stimulate sexual desire and arousal completely or mostly via activation of the MC4 receptor (the MC3 receptor may also be involved). It modulates inflammation and limits ischemia via activation of the MC1 and MC4 receptors.
According to Palatin Technologies’ for bremelanotide, it possesses approximately 50 times the potency of Melanotan II as an inducer of erection in male mice. In addition, it was stated in that the therapeutic window of bremelanotide in animals (specifically, the range of induction of the desired sexual arousal relative to the selection of side effects including nausea, yawning, stretching, and decreased appetite) was >1,000-fold, whereas that of Melanotan II was only 3- to 4-fold. They concluded that bremelanotide would be more tolerable than Melanotan II.
Where to buy Bremelanotide
International Peptide company is a top tier-supplier of PT 141 Peptide, a part of the melanocortin peptide family. As of today, PT-141 is only a research product. But, may someday be able to provide the benefits of Viagrowth IV, treat low sex drive in women, libido, erectile dysfunction, and more.
Information is for educational/research purposes only. This is not medical advice.